职称：副教授
单位：复旦大学
部门：生命科学学院
职务：无
出生年月：1976年7月，性别：男
社会职务：无
联系方式：xhhu@fudan.edu.cn
微博：无

研究领域：
        主要从事复杂性状（疾病）的遗传学机制研究。在疾病的研究方面，以发病率日趋加剧的肺癌为对象，深入研究肺癌发生发展的表观遗传调控机制，并揭示非编码RNA调控非小细胞肺癌的侵袭、转移以及干性特征的分子机制。在复杂性状研究方面，以模式生物酵母为模型，揭示了酵母细胞的乙醇耐受性、粘附、絮凝等复杂性状的分子机制。相关成果已发表在Clinical Cancer Research、Oncogene、International Journal of Cancer、Plos Genetic、DNA Research、Genetics等国际著名期刊中。

论文与著作：
已发表文章（*：并列第一作者；#：并列通讯作者）：
1. Tianchi Liu, Xiaoping Wu, Tong Chen, Zewei Luo, Xiaohua Hu# (2018) Downregulation of DNMT3A by miR-708-5p inhibits lung cancer stem cell-like phenotypes through repressing Wnt/β-catenin signaling. Clin Cancer Res, 24:1748-1760;
2. O Fang*, X Hu*, L Wang, N Jiang, J Yang et al. (2018). Amn1 governs post-mitotic cell separation in Saccharomyces cerevisiae. Plos Genet. 14(10): e1007691
3. L Chen*, X Pan*, X Hu*, YH Zhang, S Wang, et al. (2018). Gene expression differences among different MSI statuses in colorectal cancer. International Journal of Cancer. 143(7): 1731-1740; 
4. X Pan*, X Hu*, YH Zhang, K Feng, et al. (2018). Identifying Patients with Atrioventricular Septal efect in Down Syndrome Populations by Using elf-Normalizing Neural Networks and eature Selection. Genes. 9:208. 
5. Xiaoyong Pan*, Xiaohua Hu*, Yu Hang Zhang, et al. (2019) Identification of the copy number variant biomarkers for breast cancer subtypes. Mol Genet Genomics 294(1):95-110
6. Xiang Gao, Jingping Sun, Chunyu Huang, Xiaohua Hu#, Ning Jiang#, Chenqi Lu#. (2017) RNAi-mediated silencing of NOX4 inhibited the invasion of gastric cancer cells through JAK2/STAT3 signaling. Am J Transl Res. 9(10): 4440-4449. 
7. X Wu, T Liu, O Fang, W Dong, F Zhang, LJ Leach, X Hu#, Z Luo#. (2016) MicroRNA-708-5p acts as a therapeutic agent against metastatic lung cancer. Oncotarget 7(3):2417-32.
8. Q Shen, J Hu, N Jiang, X Hu, Z Luo, H Zhang. (2016) contamDE: Differential expression analysis of RNA-seq data for contaminated tumor samples. Bioinformatics 32(5):705-12.
9. Zhang H, J Xu, N Jiang, X Hu, Z Luo. (2015) PLNseq: a multivariate Poisson lognormal distribution for high-throughput matched RNA-sequencing read count data. Statistics in Medicine 34(9):1577-1589.
10. X Wu, T Liu, O Fang, LJ Leach，X Hu#, Z Luo#. (2014) miR-194 suppresses metastasis of non-small cell lung cancer through regulating expression of BMP1 and p27kip1. Oncogene 33(12):1506-1514. 
11. L Wang, N Jiang, L Wang, O Fang, Lindsey J. Leach, X Hu#, Z Luo#. (2014) 3’ Untranslated Regions Mediate Transcriptional Interference Between Convergent Genes Both Locally and Ectopically in Saccharomyces cerevisiae. PloS Genetics 10(1): e1004021. doi:10.1371/journal.pgen.1004021. 
12. J Li, L Wang, X Wu, O Fang, L Wang, C Lu, S Yang, X Hu#, Z Luo#. (2013) Polygenic Molecular Architecture Underlying Non-Sexual Cell Aggregation in Budding Yeast. DNA Res 20:55-66.
13. C Lu*，X Hu*，G Wang，LJ Leach，et al. (2010) Why do essential proteins tend to be clustered in the yeast interactome network? Mol Biosyst 6:871-877. 
14. X Wu, J Shi, M Xi, Z Luo, X Hu#. (2010) A B functional gene cloned from lily encodes an ortholog of Arabidopsis PISTILLATA (PI). Plant Mol Biol Rep 28:684-691.
15. M Wang, T Jia, N Jiang, L Wang, X Hu, Z Luo.(2010) Inferring linkage disequilibrium from non-random samples. BMC Genomics 11:328.
16. Wang M*, Hu XH*, Li G, Leach LJ, Potokina E, et al. (2009) Robust Detection and Genotyping of Single Feature Polymorphisms from Gene Expression Data. PLoS Comput Biol 5(3): e1000317. 
17. Wang L, X Hu, Z Feng, Y Pan. (2009). Development of AFLP markers and  phylogenetic analysis in Hypsizygus marmoreus. J Gen Appl Microbiol. 55(1):9-17. 
18. Wang G *, X Hu*, C Lu,C Su, S Luo, ZW Luo. (2008). Promoter-hypermethylation associated defective expression of E-cadherin in primary non-small cell lung cancer. Lung Cancer 68:162-172. 
19. Wang GY, Lu CQ, Zhang RM, Hu XH, Luo ZW. (2008). The E-cadherin Gene Polymorphism 160C/A and Cancer Risk: A HuGE Review and Meta-Analysis of 26 Case-Control Studies. Am J Epidemiol 167(1):7-14. 
20. Jiang N, LJ Leach, XH Hu, E Potokina, T Jia, A Druka, R Waugh, MJ Kearsey，ZW Luo.(2008). Methods for evaluating gene expression from Affymetrix microarray datasets. BMC Bioinformatics 9:284. 
21. Hu XH, MH Wang，T Tan, JR Li, H Yang, L Leach, RM Zhang, ZW Luo.(2007). Genetic dissection of ethanol tolerance in budding yeast S. cerevisiae. Genetics 175(3): 1479-1487. 
22. Wang JC, CC Su, JB Xu, LZ Chen, XH Hu, GY Wang, Y Bao, Q Huang, SB Fu, P Li, CQ Lu, RM Zhang, ZW Luo. (2007). Novel Microdeletion in the transforming growth factor β type II receptor gene is associated with giant and large cell variants of nonsmall cell lung carcinoma. Gene Chromosome Cancer 46(2):192-201. 
23. Xu L, H Chen, X Hu, R Zhang, Z Zhang, Z Luo. (2006). Average gene length is highly conserved in prokaryotes and eukaryotes and diverges only between the two kingdoms. Mol Biol Evol. 23(6): 1107-1108.
24. Wang M, J Wang, Z Zhang, Z Zhao, R Zhang, X Hu, T Tan, S Luo, Z Luo. (2005). Dissecting phenotypic variation among AIS patients. Biochem Bioph Res Co 335:335–342.

著作：

• GY Wang, XH Hu, RM Zhang, L Leach and ZW Luo (2008). TGF-β ligands, TGF-β receptors, and lung cancer. In Cancer Drug Discovery and Development: Transforming Growth Factor-β in Cancer Therapy. Edited by S. B. Jakowlew. Humana Press, Totowa, NJ. : Page 79-93

荣誉与奖励：

• 2016：复兴医药奖教金
• 2014：生命科学学院优秀青年教师
• 2013：生命科学学院优秀青年教师
• 2008：生物医学院优秀教师
• 2007：生物医学院优秀教师